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№ 18 — 7.146 —
№ 17 — 6.749 —
№ 16 — 6.352 —
№ 15 — 5.955 —
№ 14 — 5.558 —
№ 13 — 5.161 —
№ 12 — 4.764 —
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Human A3-adenosine receptors are somewhat more sensitive to xanthines, but at in vivo levels of 5 to 20 mM caffeine will have virtually no effect even on the human A3 receptors. By contrast, results from rodents and humans show that caffeine binds to A1, A2A, or A2B receptors with Kd values in the range of 2 to 20 mM (see Fredholm et al., 1999, 2001b). Thus, caffeine at the levels reached during normal human consumption could exert its actions at A1, A2A, or A2B receptors, but not by blocking A3 receptors.
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Grobbee D.E. Coffee, Caffeine, and Cardiovascular Disease in Men / D. E. Grobbee, E. B. Rimm, E. Giovannucci, G. Colditz, M. Stampfer, W. Willett // N. Engl. J. Med. – 1990. – . 323 – № 15 – 1026–1032.
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Ascherio A. Prospective Study of caffeine consumption and risk of Parkinson’s disease in men and women / A. Ascherio, S. M. Zhang, I. Kawachi, G. A. Colditz, W. C. Willett, M. A. Hernan, F. E. Speizer // Ann. Neurol. – 2001. – . 50 – № 1 – 56–63.
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Van Dam R. M. et al. Coffee, Caffeine, and Risk of Type 2 Diabetes A prospective cohort study in younger and middle-aged US women //Diabetes Care. – 2006. – . 29. – №. 2. – . 398-403.
Coffee, cirrhosis, and transaminase enzymes. Klatsky AL; Morton C; Udaltsova N; Friedman GD Arch Intern Med. 2006 Jun 12;166(11):1190-5.
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Coffee consumption and mortality in a 14-year follow-up of an elderly northern Finnish population. Happonen P; Laara E; Hiltunen L; Luukinen H Br J Nutr. 2007 Dec 6;:1-8.
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